ClinConnect ClinConnect Logo
Search / Trial NCT07019844

PSMA PET for the Staging and Management of Hepatocellular Carcinoma

Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Jun 5, 2025

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called F18-Piflufolastat (PSMA) PET/CT to see how well it works for diagnosing and managing liver cancer known as hepatocellular carcinoma (HCC). The researchers want to find out if using this advanced imaging method, along with traditional imaging tests, can give doctors better information about liver lesions and help them make more accurate decisions about treatment and care for patients with HCC.

To be eligible for the trial, participants must be adults over 18 years old who are new patients with HCC that falls into specific stages of the disease (BCLC B or C). However, people with certain health issues, like kidney problems or other active cancers, are not able to join. If you participate, you can expect to undergo additional imaging tests and help researchers understand how this new PET scan could improve the diagnosis and treatment of liver cancer. The trial is currently recruiting participants, and everyone is welcome, regardless of gender.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adult patients age \>18 years from the VA medical system
  • Treatment-naïve patients with HCC with BCLC B or C disease
  • Exclusion Criteria:
  • Patients with renal dysfunction or contrast allergy that precludes contrast enhanced cross sectional imaging
  • Patients with presence of active primary malignancy other than HCC and non-melanoma skin cancer in the past 3 years

About Va Office Of Research And Development

The VA Office of Research and Development (ORD) is dedicated to advancing the health and well-being of veterans through innovative research initiatives. As a pivotal sponsor of clinical trials, ORD focuses on a broad spectrum of health-related topics, including mental health, rehabilitation, and chronic disease management, ensuring that findings are directly applicable to the unique needs of the veteran population. With a commitment to scientific excellence and collaboration, ORD promotes rigorous study designs and ethical standards, facilitating the translation of research discoveries into improved clinical practices and policies that enhance veteran care.

Locations

Miami, Florida, United States

Miami, Florida, United States

Patients applied

0 patients applied

Trial Officials

Binu V John, MD MPH

Principal Investigator

Miami VA Healthcare System, Miami, FL

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported