Comparing PCCT With ICA and IVUS in Detecting Cardiac Allograft Vasculopathy

Launched by SAHLGRENSKA UNIVERSITY HOSPITAL · Jun 5, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technique called photon-counting computed tomography (PCCT) to see how well it can detect changes in the arteries of heart transplant patients compared to traditional methods like coronary angiography (ICA) and intravascular ultrasound (IVUS). Heart transplant patients often don't feel any symptoms of heart problems, so routine check-ups are important to catch issues early. The goal of this study is to find out if PCCT can be as effective or better than the existing methods for monitoring heart health after a transplant.

To participate in this trial, you need to be an adult who has received a heart transplant and is currently stable. You should also be scheduled for a routine coronary angiography and be able to give your consent to join the study. However, people with certain health issues, such as allergies to the contrast dye used in these tests or serious kidney problems, won't be eligible. If you join, you can expect to undergo imaging tests that are designed to help researchers determine the best way to monitor heart health in transplant patients. This research could lead to improved care for individuals with heart transplants in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult heart transplant recipients.
• • Clinically stable and scheduled for routine ICA.
• • Ability to provide informed consent
• Exclusion Criteria:
• • Contrast allergy
• • Renal insufficiency with eGFR \< 30 ml/min/m2
• • Other contraindications for PCCT, ICA, or IVUS
• • Acute cardiac events within 30 days prior to enrollment.