Impact of Frequency-specific Subthalamic Nucleus Subregion Stimulation on Inhibitory Control in Parkinson's Disease

Launched by BEIJING TIANTAN HOSPITAL · Jun 7, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different types of electrical stimulation in a specific brain area called the subthalamic nucleus (STN) can improve the ability to control impulses and attention in people with Parkinson's disease (PD). Parkinson's can lead to problems not just with movement, but also with thinking and memory. This trial will look at patients who have already had a surgery called deep brain stimulation (DBS) to see if using low or high-frequency stimulation in different parts of the STN can help improve cognitive functions like inhibitory control, which is important for managing impulsive behavior.

To participate in this study, individuals need to be between 40 and 80 years old, diagnosed with Parkinson's disease, and meet certain requirements for DBS surgery. Those who join the study will undergo various tests while receiving different types of stimulation and will help researchers identify which methods work best for improving cognitive control. This research is important because finding effective ways to enhance cognitive function could significantly improve the quality of life for people living with Parkinson's.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 40-80 years old;
• • 2. Diagnosed with idiopathic Parkinson's disease;
• • 3. Meeting the indications for DBS surgery.
• Exclusion Criteria:
• • 1. Patient declined to participate in the study;
• • 2. Presence of significant post-DBS complications (e.g., intracranial hemorrhage, cerebral edema, electrode misplacement);
• • 3. Significant psychiatric disorders or dementia (MMSE score \<20 for uneducated; \<23 for 1-6 years education; \<27 for ≥7 years education);
• • 4. Visual or auditory impairment affecting cognitive task performance
• • 5. History of conditions potentially impairing cognitive function.