Postpartum Evaluation of Nifedipine and Enalapril for Hypertension

Launched by NEBRASKA METHODIST HEALTH SYSTEM · Jun 8, 2025

Keywords

ClinConnect Summary

This clinical trial is studying two medications, nifedipine and enalapril, to see how well they control high blood pressure in women after childbirth. The goal is to find out if both medicines are just as effective in managing blood pressure and preventing any complications that might require a return to the hospital after delivery. This study is for women who had high blood pressure during pregnancy, whether it was a pre-existing condition or developed during pregnancy. If you are a woman who has been admitted for delivery after 24 weeks of pregnancy and your blood pressure is high, you may be eligible to participate.

If you decide to join the study, you will be randomly assigned to take either nifedipine or enalapril as part of your care. The doctors will monitor your blood pressure, but any further decisions about your treatment, like changing medications or dosages, will be made by your primary healthcare provider. This trial is not yet recruiting participants, but it aims to ensure both medications are safe while helping you manage your blood pressure effectively after giving birth.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. admitted for delivery by cesarean or vaginal delivery
• • 2. 24 weeks gestation or greater
• • 3. Pregnancy related hypertension(HTN) or chronic hypertension. Pregnancy related hypertension will be defined during the study as either a systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg on two occasions at least 4 hours apart. This definition is consistent with the ACOG definition for pregnancy related HTN in patients without CHTN.
• Exclusion Criteria:
• • 1. Absolute contraindication to either nifedipine or enalapril Relative contraindications will be reviewed with PI.
• • 2. Persistent HR \<60 or \>110
• • 3. Native language other than English