PENG Block Optimization: Volume and Dexamethasone Effects

Launched by POZNAN UNIVERSITY OF MEDICAL SCIENCES · Jun 8, 2025

Keywords

ClinConnect Summary

This clinical trial, called "PENG Block Optimization: Volume and Dexamethasone Effects," is designed to explore how different amounts of a local anesthetic and an anti-inflammatory medication affect pain management for patients undergoing total hip replacement surgery. The study will look at how well these treatments help reduce pain after surgery, how much pain-relief medication participants need, and how they affect muscle function. Participants will be randomly assigned to receive one of four different treatment options, which vary in the volume of the anesthetic used and whether or not they receive the additional medication.

To qualify for this trial, you must be an adult aged 18 or older who is scheduled for a single hip replacement surgery. You should be in good health overall, able to understand and agree to the study, and your body weight should fall within a certain range. Unfortunately, if you have allergies to the medications being tested, certain medical conditions, or if you are pregnant or breastfeeding, you won't be able to participate. If you join the study, you can expect to receive care and follow-up assessments to monitor your recovery and pain levels after the surgery. This trial is not yet recruiting participants, but it aims to provide valuable insights into improving pain management for hip surgery patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged ≥18 years scheduled for primary unilateral total hip arthroplasty (THA).
• • American Society of Anesthesiologists (ASA) physical status I-III.
• • Ability to provide written informed consent.
• • Spinal anesthesia planned as the primary anesthetic technique.
• • Body mass index (BMI) between 18 and 35 kg/m².
• • Fluent in the local language and able to understand the NRS pain scoring system.
• Exclusion Criteria:
• • Known allergy or hypersensitivity to ropivacaine, dexamethasone, or other amide local anesthetics.
• • Pre-existing neurological deficits or neuropathies affecting lower limb motor or sensory function.
• • Chronic opioid use (daily use \>30 mg oral morphine equivalents for \>1 month prior to surgery).
• • History of coagulopathy, current anticoagulant therapy not eligible for regional anesthesia.
• • Uncontrolled diabetes mellitus (HbA1c \> 9%) or active systemic infection.
• • Pregnancy or breastfeeding.
• • Previous surgery or implantation on the ipsilateral hip.
• • Inability to cooperate with postoperative assessments or participate in follow-up.