Genicular Embolization Using Doxycycline Sclerotherapy

Launched by CAMPBELL CLINIC · Jun 9, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment for people who have ongoing knee pain due to osteoarthritis and cannot have surgery. The treatment involves a procedure called genicular embolization, where a medicine called doxycycline is used to help reduce pain by targeting specific blood vessels in the knee. The main goal is to find out if this treatment is safe and helps reduce knee pain over a period of three months, with additional checks up to a year later.

To join this study, participants need to be adults with moderate knee arthritis and significant pain in one knee. They should be able to speak and understand English, agree to follow-up visits, and not have had recent knee surgery or steroid injections. People with allergies to doxycycline or related substances cannot participate. If eligible, participants will receive the treatment and be asked to rate their pain and knee function over time using simple questionnaires. This study is still in the early stages and has not started recruiting yet.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • At least 18 years of age or older.
• • KL Score 2-3
• • VA Grade \>5
• • Native knee
• • Willing and able to provide consent.
• • Willing and able to complete questionnaires.
• • Willing and able to complete follow up visits.
• • Speak and write fluent English
• • Unilateral knee (if bilateral knee pain, identify knee for procedure)
• • All subjects may be included regardless of sex. Women must be either surgically sterilized postmenopausal defined as having no menstrual periods for 12 consecutive months
• Exclusion Criteria:
• • Allergies to doxycycline or any other substances used in procedure
• • Steroid injection in the index knee within the last 90 days
• • Knee surgery on index knee in the last 180 days