Proteomic and Histological Analysis of Ligamentum Flavum in Lumbar Stenosis

Launched by FONDAZIONE POLICLINICO UNIVERSITARIO AGOSTINO GEMELLI IRCCS · Jun 10, 2025

Keywords

ClinConnect Summary

This clinical trial is studying lumbar spinal stenosis, a condition where the space around the spinal cord in the lower back becomes narrow, often causing pain and difficulty walking. The researchers are focusing on a specific part of the spine called the ligamentum flavum, a ligament that can thicken and contribute to this narrowing. By examining tissue samples from patients who have surgery for this condition, the study aims to understand the changes in proteins and tissue structure that cause the ligament to thicken. This could help doctors develop better ways to diagnose and treat lumbar spinal stenosis in the future.

People aged 50 to 85 who have been diagnosed with lumbar spinal stenosis through imaging tests like MRI or CT scans may be eligible to participate, as long as they do not have certain other conditions like spine infections, tumors, or genetic bone disorders. Participants will provide tissue samples during their planned surgery, which will then be studied to find markers that explain the disease better. While the trial is not yet recruiting, it hopes to lead to new treatments that could slow down the disease and improve quality of life for patients with spinal stenosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Radiological (CT and/or MRI) and clinical evidence of lumbar spinal stenosis (LSS).
• • Age range: 50-85 years.
• • Signed informed consent, medical records release form, and HIPAA authorization form (or equivalent according to local regulations), reviewed and signed by the patient or legally authorized representatives.
• Exclusion Criteria:
• • Pediatric population and individuals under 50 years of age.
• • Concomitant genetic musculoskeletal disorders.
• • History of trauma.
• • Spinal infections (spondylodiscitis, osteomyelitis, abscess, etc.).
• • Presence of spinal tumors or other neoplasms.