Pars Plana Vitrectomy and Influence of Perfluorocarbon Liquids on Retinal Displacement

Launched by NORFOLK AND NORWICH UNIVERSITY HOSPITALS NHS FOUNDATION TRUST · Jun 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a type of eye surgery called pars plana vitrectomy (PPV), which is used to fix a serious condition called retinal detachment. Retinal detachment happens when the light-sensitive layer at the back of the eye (the retina) pulls away from its normal position, which can threaten your sight. Even after successful surgery, some patients notice visual problems like distortion or blind spots because the retina can sometimes shift slightly out of place when it reattaches. This study wants to understand how a special liquid used during surgery, called perfluorocarbon liquid (PFCL), affects this shifting and the patient’s vision afterward.

Adults aged 18 and older who have a specific type of retinal detachment with the center of their vision affected may be eligible for this study, as long as they haven’t had previous retinal surgeries in that eye and meet other health criteria. If you join, you’ll have surgery where the doctor may or may not use PFCL, and the study team will check your retina using advanced imaging tools before and after surgery. They will also ask about your vision and any visual changes you notice. The goal is to learn if using PFCL helps improve how the retina heals and how well patients see after surgery. This information could help doctors choose the best surgical methods in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age, or older.
• • Diagnosis of primary MIRD with posterior vitreous detachment, and fovea off (confirmed with OCT)
• • Surgeons' decision that the patient is eligible for using gas as postoperative tamponade.
• • The surgeon is confident to proceed with surgery with or without the use of intraoperative PFCL
• Exclusion Criteria:
• • Previous RRD and/or RRD surgery in the study eye
• • Decision to use adjunct scleral buckle
• • Decision to use silicone oil as tamponade
• • Retinal detachment with macula on
• • Patients with other retinal pathologies causing permanent structural changes to the retina in the study eye, such as diabetic retinopathy (assessed above background, or any diabetic maculopathy), previous vascular occlusion (artery or vein occlusion), macula dystrophy, among others
• • Previous vitreoretinal surgery in the study eye
• • Inability to come for follow ups up to 3 months
• • Inability to take FAF and OCT imaging due to neck stiffness or other medical issue
• • Mental incapacity
• • Patient is unwilling or unable to follow or comply with all study related procedures or to sign informed consent form.
• • Contraindications for PFCL
• • Previous enrollment in a clinical trial involving retinal diseases and/or treatments
• • Media opacity leading to poor quality retinal images (not including post operative significant cataract. See section 7.11)
• • Patient inability to posture following surgery