Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity
Launched by UNIVERSIDADE FEDERAL DO PARA · Jun 10, 2025
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is studying whether a new gel made with cannabidiol (CBD) oil can help reduce tooth sensitivity caused by teeth whitening treatments. When teeth are whitened using a strong bleaching agent, some people experience discomfort or pain. This study will compare the experimental CBD gel to a placebo gel (which has no active ingredient) and a commonly used gel that contains potassium nitrate and fluoride, both known to help with sensitivity. Volunteers will have one of these gels applied to their teeth for 10 minutes before undergoing a professional teeth whitening treatment. Afterward, participants will record how sensitive their teeth feel each day for three weeks.
To take part, volunteers need to be in good overall and oral health and have at least 28 natural teeth. People with active cavities, gum disease, cracks, or certain dental problems won’t be eligible, nor will smokers, pregnant or breastfeeding women. During the study, participants will be asked to rate their tooth sensitivity using a simple pain scale and answer questions about their experience after each whitening session. This trial is not yet recruiting, but it aims to find out if the CBD gel can be a helpful option for people who want to whiten their teeth without discomfort.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participants must have at least 28 teeth in the cavity
- • Good oral and general health
- Exclusion Criteria:
- • active caries or periodontal disease
- • visible cracks in front teeth upper or lower
- • with evident malocclusion
- • restorations and prosthetics in teeth anterior teeth
- • gastroesophageal disorders
- • severe internal tooth discoloration (tetracycline , fluorosis or pulped teeth)
- • dentin exposure in anterior teeth and /or later
- • parafunctional habits
- • tooth sensitivity
- • whitening treatment prior to or undergoing orthodontic treatment
- • Furthermore, smokers, pregnant or breastfeeding women do not will be included.
About Universidade Federal Do Para
The Universidade Federal do Pará (UFPA) is a prominent Brazilian institution dedicated to advancing research and education in various fields, including health sciences. As a clinical trial sponsor, UFPA leverages its extensive academic resources and expertise to design, implement, and oversee innovative research studies aimed at improving health outcomes and contributing to the scientific community. The university fosters collaboration among researchers, healthcare professionals, and stakeholders to ensure rigorous methodologies and ethical standards are upheld throughout the research process, ultimately striving to translate findings into practical applications that benefit public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Belém, Pa, Brazil
Patients applied
Trial Officials
Jesuína L Nogueira Araújo, PHD
Principal Investigator
Federal University of Pará
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported