Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Launched by MAREA THERAPEUTICS · Jun 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medicine called MAR001 to see if it can help lower high levels of triglycerides and remnant cholesterol in adults. Triglycerides and remnant cholesterol are types of fats in the blood that, when too high, can increase the risk of heart problems. The study will compare MAR001 to a placebo (a pill with no active medicine) to see if it works better at reducing these fat levels.

Adults who have higher than normal levels of these blood fats, along with certain cholesterol levels, may be able to join the study. Participants need to have a stable diet and medication routine before starting and throughout the study. People with serious liver problems, very high triglycerides, certain types of diabetes, or active hepatitis infections will not be eligible. Those who join will be asked to follow the study rules closely and attend regular check-ups to see how the medicine is working. The trial is not yet recruiting participants but aims to include adults of all genders who meet these health requirements.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Elevated fasting TGs and RC
• • Elevated nonfasting TGs and RC
• • Fasting LDL-C ≥ 50 mg/dL (≥ 1.29 mmol/L) and ≤ 130 mg/dL (≤ 3.36 mmol/L)
• • Willingness to provide informed consent and comply with the intervention and all study assessments
• • Stable diet for a minimum of 3 months prior to screening and with no plans to change diet through duration of study
• • Stable drug regimen (if relevant) prior to screening visit and no planned changes during screening or trial participation
• Exclusion Criteria:
• • Acute or chronic liver disease
• • TG concentration ≥880mg/dl
• • History of type 1 diabetes mellitus or history of diabetic ketoacidosis
• • Newly diagnosed T2DM
• • Participants with known active hepatitis A, B, or C
• • Uncontrolled hypothyroidism
• • Any condition that prevents the participant from complying with study procedures