Effectiveness of Low Volume Versus High Volume of Local Anesthetic in Ultrasound Guided Combined Supraclavicular and Interscalene Block for Upper Limb Surgery

Launched by MISR UNIVERSITY FOR SCIENCE AND TECHNOLOGY · Jun 11, 2025

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ClinConnect Summary

This clinical trial is studying whether using a smaller amount of local anesthetic (numbing medicine) works just as well as a larger amount when given as a nerve block for pain relief during and after upper limb (arm) surgery. The nerve block is done using ultrasound guidance to carefully place the medicine around specific nerves near the shoulder and neck. Researchers want to see if the smaller amount can provide the same pain relief while causing fewer side effects or complications.

Adults aged 18 to 65 who are generally healthy (with no serious health problems) and scheduled for upper limb surgery may be eligible to join. Participants will be randomly assigned to receive either a low volume (15-20 ml) or a high volume (30-40 ml) of the local anesthetic during their surgery. The study will monitor how well the pain relief works and watch for any possible side effects, such as breathing difficulties or bleeding. If you are considering joining, it's important to know that people with allergies to the anesthetic, certain nerve problems, bleeding disorders, or severe lung disease will not be eligible. Participants can expect careful monitoring and support throughout the process to ensure safety and comfort.

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Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 to 65 of both sexes
• • ASA classification I or II
• • Scheduled for upper limp surgery
• • Will be randomized 1:1 into two groups; group A; low volume local anesthetics (15-20ml) and group B; high volume local anesthetics (30-40 ml).
• Exclusion Criteria:
• • Patients who refuse participation.
• • Have allergies to local anesthetics.
• • Phrenic nerve dysfunction.
• • Chronic opioid use.
• • ASA III or higher classification.
• • Coagulopathy (bleeding disorders with INR \> 1.5 and/or platelets \< 50 000)
• • Severe chronic obstructive pulmonary disease.
• • Local infection at the injection site