Screening for Alterations in the Autonomic Nervous System

Launched by UNIVERSITY HOSPITAL, ANGERS · Jun 11, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to help diagnose dysautonomia, a condition where the autonomic nervous system (which controls automatic body functions like heart rate and blood pressure) doesn’t work properly. Dysautonomia can cause serious symptoms and is common in people with diabetes. Right now, diagnosing this condition requires special tests that are hard to access. This study wants to see if a device called ACCUVEIN, which uses a light projection to show veins under the skin, can detect changes in vein size when a person stands up. If it works, this device could become a simple and quick tool to help identify problems with the nervous system in people with dysautonomia.

The study is looking for healthy adults between 18 and 40 years old who don’t have chronic illnesses, heart problems, or symptoms of dysautonomia. Participants must also be non-smokers and not regularly drink excessive alcohol. Those who join will have their veins examined using the ACCUVEIN device while changing positions, such as moving from sitting to standing. This helps researchers see if the device can detect normal vein changes linked to nervous system activity. If you’re interested and meet these criteria, you might help improve how dysautonomia is diagnosed in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects between the ages of 18 and 40
• • Subject affiliated with or benefiting from a social security plan
• • Subject having signed an informed consent form
• • Subject without known chronic illness or long-term treatment (oral contraceptive authorized for women)
• • Subject without symptoms of dysautonomia
• • Subject with no history of cardiovascular disease
• • No history of loss of consciousness
• • Subjects without regular and excessive alcohol consumption according to the WHO
• • Non-smoker, non-vapoteur
• • No chronic pain
• Exclusion Criteria:
• • Known ECG abnormality
• • Pregnant women, parturients and nursing mothers
• • Person deprived of liberty by administrative or judicial decision
• • Person under compulsory psychiatric care
• • Adult subject to a legal protection measure
• • Persons unable to express their consent
• • Subject unable to understand study objectives or instructions
• • Subject in a period of exclusion from another study