Effectiveness of Coenzyme Q10 and Probiotics in Periodontal Therapy During Pregnancy

Launched by UNIVERSITY OF PAVIA · Jun 11, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether adding coenzyme Q10 (a natural antioxidant) and probiotics (good bacteria) to regular dental care can help improve gum health in pregnant women. The researchers want to see if this combination can reduce dental plaque and gum inflammation better than standard cleaning alone. Forty pregnant women will take part, with half receiving a special toothpaste containing coenzyme Q10 plus daily probiotics, while the other half will use the same toothpaste without probiotics. Everyone will get professional teeth cleaning every three months, and the study will last six months.

Women who are between their 4th and 8th month of pregnancy, at least 18 years old, and able to communicate in Italian or English may be eligible to join. Participants will need to follow study instructions and attend regular dental visits. The study will measure how well the treatments reduce plaque, bleeding, and other signs of gum disease. This research hopes to find safe and helpful ways to keep gums healthy during pregnancy, which is important for both mother and baby.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pregnant women between the 4th and 8th month of gestation
• • Age ≥ 18 years
• • Able to understand and communicate in Italian and/or English
• • Willing to provide written informed consent
• • Good compliance and willingness to follow study instructions
• Exclusion Criteria:
• • Presence of cardiac pacemakers
• • Diagnosed psychological, neurological, or psychiatric disorders
• • Ongoing oncological therapy
• • Use of bisphosphonates within the last 12 months
• • Poor motivation or low compliance
• • Substance abuse (drugs or alcohol) or lifestyle incompatible with study requirements