A Randomized Double Blind, Placebo Controlled Clinical Study Evaluating the Efficacy and Safety of Magnesium Supplementation on Relaxation in Adults

Launched by OLLY, PBC · Jun 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether taking a daily magnesium supplement can help improve relaxation and sleep in healthy adults. The researchers want to see if magnesium can reduce stress and help people feel more relaxed in both body and mind, compared to a placebo (a “dummy” pill with no active ingredient). Participants will take the supplement every day for 12 weeks and complete monthly check-ins and questionnaires about their stress and sleep. They will also keep a journal to note any side effects or other health changes during the study.

To join the study, you need to be a healthy adult willing to keep your usual diet and exercise habits, and be able to follow the study’s schedule for visits and assessments. People with certain health conditions, those who are pregnant or breastfeeding, or those taking medications that could interact with magnesium will not be eligible. The study is open to adults of all genders but excludes anyone with a body mass index (BMI) over 40 or who might have difficulty completing the study reliably. If accepted, participants can expect to take a daily supplement, fill out questionnaires about their relaxation and sleep, and report any health changes over three months. This study has not started recruiting yet, so keep an eye out if you’re interested in participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy participants (women + men)
• • Will maintain regular diet and exercise habits
• • Agreement to adhere to the procedures and requirements of the study and to report to the institute on the day(s) and at the time(s) scheduled for the assessments.
• Exclusion Criteria:
• • 1. Neurological or psychiatric disorders
• • 2. Pregnant or breastfeeding
• • 3. Known allergies to magnesium-containing products
• • 4. Taking a medication known to interact with magnesium, or taking loop diuretics, cyclosporine, digoxin, amphotericin.
• • 5. No concurrent magnesium supplementation
• • 6. Substance or alcohol abuse
• • 7. Currently use, or have used within appropriate washout period, any prescription, over the counter medication, or supplements with primary CNS activity such as Antidepressants,mood stabilizer and anxiolytics, Sedatives and Stimulants
• • 8. Anticholinergic or cholinergic medications
• • 9. Anti-inflammatory and analgesic medication (except for PRN use)
• • 10. Anti-allergy medication (except for non-sedating antihistamines)
• • 11. Blood thinners
• • 12. Other prescribed medications that may affect cognition, stress, or mood
• • 13. Body mass index (BMI) greater than 40 kg/m2 ,
• • 14. Individuals on angiotensin converting enzyme inhibitors for blood pressure control, other magnesium-retaining drugs, or potassium-sparing drugs
• • 15. History of reaction to the category of product tested
• • 16. Other diseases or medications that might directly interfere in the study or put the subject's health under risk.
• • 17. Subjects with any invasive medical procedures during the study.
• • 18. Participants who are unreliable or unlikely to be available for the duration of the study.
• • 19. No employees of PCR or the sponsor (e.g OLLY PBC, Unilever, or the H\&W Collective)