The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP

Launched by LANYUE ZHU · Jun 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how frailty before surgery might affect the chances of developing acute kidney injury (AKI) after surgery. Frailty means being physically weaker or more vulnerable, often due to age or health conditions. The study will also explore how changes in blood pressure during surgery might play a role in causing kidney problems afterward. Researchers want to understand if frail patients are more likely to have these issues compared to those who are not frail.

The study is open to adults aged 18 and older who are having non-heart-related surgery lasting more than two hours. People with very severe kidney problems, recent kidney injury, or missing important health tests won’t be able to join. Participants will have their frailty assessed and their blood pressure closely monitored during surgery. The study will track any kidney problems after surgery, other complications, how long patients stay in the hospital, and the overall costs of their care. This information could help doctors better manage patients who are frail and reduce the risk of kidney injury after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years old or above
• • Undergo non-cardiac surgery
• Exclusion Criteria:
• • At least one measurement of serum creatinine (SCr) was not conducted before and after the operation
• • End-stage renal disease (ESRD) that has received dialysis within the past year
• • Baseline SCr ≥ 4.5 mg/dl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)
• • Acute kidney injury occurred within 7 days before the operation
• • No frailty assessment was conducted
• • The operation time is less than 2 hours