Comparison of Arthrogenic Muscle Inhibition (AMI) After ACL Reconstruction in Patients With Conventional Rehabilitation or Conventional Rehabilitation Combined With Digital Therapy

Launched by GCS RAMSAY SANTÉ POUR L'ENSEIGNEMENT ET LA RECHERCHE · Jun 12, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how well a new digital therapy program, called DOCT'UP®, helps people recover after surgery to fix a torn anterior cruciate ligament (ACL) in the knee. After ACL surgery, many patients experience something called arthrogenic muscle inhibition (AMI), which means their thigh muscles don’t work as well as they should, even though the nerves and muscles are physically okay. This can slow down recovery and make it harder to get back to normal activities. Traditional rehab exercises don’t always fully fix this problem, and sometimes it’s hard for patients to stick with their rehab at home. The DOCT'UP® program is designed to be used alongside regular physiotherapy and offers extra support and exercises through a smartphone app to help improve muscle function, reduce pain, and speed up recovery.

People who might join this study are adults (18 years or older) who are scheduled to have their first ACL reconstruction surgery and who have a smartphone they can use for the app. Participants need to speak French, have internet access, and be able to take part in physical exercises safely. If you join, you’ll follow a rehab program that includes usual physiotherapy plus the digital therapy app, which guides you through exercises and education to help your muscles heal better. The study aims to see if using this app makes recovery faster and more effective compared to traditional rehab alone. This trial is not yet recruiting, but it hopes to help improve how people recover from ACL surgery in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient, male or female, aged ≥ 18 years
• • Patient with a scheduled primary ACL reconstruction
• • Patient with a smartphone and able to use a mobile application on a smartphone
• • Patient affiliated to or benefiting from a social security scheme
• • French-speaking patient who has signed an informed consent form
• Exclusion Criteria:
• • Patients with residual AMI
• • Patient with previous ipsi or contralateral knee surgery
• • Patient with a multi-ligament injury
• • Patient with contraindications to physical exercise: severe cardiovascular disease or uncontrolled metabolic disease
• • Patients with cognitive problems
• • Patient without internet access
• • Patient taking part in another study
• • Pregnant or breast-feeding women
• • Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision