A Study of LY3549492 in Adults With Obesity or Overweight With Type 2 Diabetes

Launched by ELI LILLY AND COMPANY · Jun 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medication called LY3549492 to see how well it works in adults who are overweight or have obesity and also have type 2 diabetes. The goal is to compare the effects of this medicine to a placebo, which is a treatment that doesn’t contain the active drug, to understand if LY3549492 can help manage weight and diabetes better. The study will last about 11 months and is currently not yet recruiting participants.

Adults who have a body mass index (BMI) of 27 or higher (which means they are overweight or obese) and have type 2 diabetes may be eligible to join. Participants need to have had a stable weight for the last three months before starting the study. People who are pregnant, have certain heart problems, recent serious illnesses, or a history of some other health issues like pancreatitis or liver disease, will not be able to participate. Those who join will be carefully monitored throughout the study to check how the treatment affects their weight and diabetes, and to make sure it is safe. This trial is open to both men and women who meet the criteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• W8M-MC-GN02:
• • Assigned male at birth
• • Assigned female at birth, who are of non-childbearing potential
• • Have type 2 diabetes
• W8M-MC-CWMM:
• • Have a BMI ≥27 kilograms per square meter (kg/m²)
• • Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss
• Exclusion Criteria:
• W8M-MC-GN02:
• • Individuals who are of childbearing potential
• • Have a history of acute or chronic pancreatitis
• * Have any of the following cardiovascular conditions within 6 months prior to screening:
• • acute myocardial infarction
• • cerebrovascular accident (stroke)
• • unstable angina, or
• • hospitalization due to congestive heart failure.
• W8M-MC-CWMM:
• • Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening
• • Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma
• • Have poorly controlled hypertension
• • Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease
• • Have a history of symptomatic gallbladder disease within the past 2 years
• • Have a lifetime history of suicide attempts