The COMFORTage Project at Ace Alzheimer Center Barcelona

Launched by FUNDACIÓ ACE INSTITUT CATALÀ DE NEUROCIÈNCIES APLICADES · Jun 12, 2025

Keywords

ClinConnect Summary

The COMFORTage study at Ace Alzheimer Center Barcelona is looking at whether a special program of personalized mental and physical activities can help slow down memory loss and thinking problems in people with mild cognitive impairment (MCI) or early-stage Alzheimer’s disease. The program uses digital tools for training and happens once a week for a year, with participants closely monitored for two years. Researchers will gather information through memory tests, brain scans, blood and fluid samples, and even recordings of participants’ speech from home to better understand how the program might help.

This study is open to people aged 60 to 85 who have been diagnosed with mild memory or thinking difficulties, are comfortable using digital devices like smartphones or tablets, and can come to the center for regular sessions. Those who join will either take part in the training program or continue with their usual care while being regularly checked by the research team. The goal is to see if this personalized approach can keep memory and daily function stronger for longer and improve quality of life. The information collected will also help create smart digital tools to support people living with dementia in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 60 and 85 years.
• • Diagnosis of MCI based on Petersen criteria with a CDR score of 0.5.
• • Diagnosis of mild AD dementia according to National Institute on Aging-Alzheimer's Association (NIA-AA) criteria with a CDR score of 1.
• • Proficiency in using digital tools such as mobile apps, tablets, or computers.
• • Ability and willingness to attend regular in-person sessions at Ace Alzheimer Center Barcelona.
• • Provided written informed consent after receiving a full explanation of the study.
• Exclusion Criteria:
• • History of traumatic brain injury.
• • Diagnosis of severe depression.
• • History of stroke or brain tumors.
• • Presence of significant uncorrected visual or auditory impairments.
• • Lack of access to a digital device or internet connection.
• • Inability to participate in regular in-person sessions at the study site.
• • Any medical condition that may confound cognitive assessment or limit participation.