Observation and Study on the Application of Different Analgesic Regimens in Critically Ill Patients Without Mechanical Ventilation

Launched by PEKING UNIVERSITY PEOPLE'S HOSPITAL · Jun 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different pain-relief methods work for critically ill patients who are not on a breathing machine (ventilator) but still need medication to manage moderate to severe pain. Since pain is common in the Intensive Care Unit (ICU), doctors use medicines to help reduce discomfort and stress, which can improve patients’ recovery. However, these pain medicines can sometimes cause side effects like breathing problems or stomach issues. This study aims to observe and compare various pain treatments to find the safest and most effective ways to help patients feel better without causing unwanted problems.

Patients who are 18 to 75 years old, staying in the ICU for more than a day, and experiencing moderate to severe pain that requires medication might be eligible to take part. Participants will be closely monitored to see how different pain medicines affect them, including the type of drugs used, how long they take them, and the total doses. The study will help doctors understand how to tailor pain relief better for patients who are not using ventilators. If you join, you can expect careful observation and assessment of your pain and treatment, but no experimental drugs will be given since this is an observational study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 and ≤75 years; Non-mechanically ventilated patients (including post-extubation patients) with an anticipated ICU stay \>24 hours; Patients with moderate to severe pain requiring analgesic therapy; Informed consent obtained from the patient or legal guardian.
• Exclusion Criteria:
• • Age \<18 or \>75 years; Pregnancy or lactation; Patients scheduled for general anesthesia surgery within 48 hours; Severe pre-existing parenchymal liver disease with clinically significant portal hypertension, Child-Pugh Class C cirrhosis, or acute liver failure; Bronchial asthma, COPD, or myasthenia gravis patients; Severe traumatic brain injury, brain tumors, intracranial hypertension, or other conditions predisposing to respiratory depression; History of alcohol or drug abuse; Any condition impairing cognitive assessment (e.g., language/sensory impairment or psychiatric disorders, such as aphasia or organic mental dysfunction); Inability to obtain informed consent or authorization; Participation in other investigational clinical trials within 6 months prior to screening; Known allergy to the study medication.