Topic Simvastatin for Bone Regeneration

Launched by UNIVERSIDAD DE GRANADA · Jun 12, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether applying a medicine called simvastatin directly to the area where a lower wisdom tooth is removed can help the bone heal better. The researchers want to see if simvastatin can reduce bone loss and improve bone strength after tooth extraction. They will also check if it helps soft tissues heal faster and if it affects pain, swelling, or jaw stiffness after surgery. The study will compare different ways of applying simvastatin to find out which method works best. Participants will have scans before and 12 weeks after the procedure to measure bone healing, and their pain and swelling will be checked several times in the first week after surgery.

People who might join this study are adults who need their lower wisdom teeth removed, have healthy overall medical conditions, and meet specific dental criteria. Pregnant women, smokers, and those taking certain medications or with specific health problems won’t be eligible. If you join, you will receive one of four treatments applied to the tooth socket after extraction, and your recovery will be closely monitored through scans and follow-up visits. This study is currently looking for participants and aims to find better ways to help bone heal after tooth removal.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Anesthetic risk ASA I-II.
• • Patients with the adjacent tooth in the mouth (37 or 47).
• • Third molars with fully developed roots.
• • Mandibular third molars included or semi-included.
• • With indication for extraction.
• • Signed informed consent.
• Exclusion Criteria:
• • Pregnant or lactating women.
• • Chronic smokers.
• • Patients with decompensated metabolic disease.
• • Patients with motor difficulties that prevent or hinder hygiene.
• • Patients who are using statins to treat hypercholesterolemia.
• • Patients under treatment with drugs that could affect the osseointegration process such as chemotherapy drugs, bisphosphonates, corticosteroids or immunosuppressants.
• • Patients with metabolic bone diseases or who have undergone radiotherapy in the last five years.