Exploration of a Novel Prognostic Prediction Model for Liver Cirrhosis

Launched by JUAN KANG · Jun 19, 2025

Keywords

ClinConnect Summary

This clinical trial is studying liver cirrhosis, a condition where the liver becomes damaged and scarred over time, affecting how it processes nutrients and produces energy. The researchers want to explore how nutrition affects the health and outlook of people with cirrhosis. Malnutrition, or poor nutrition, is very common in cirrhosis and can have a big impact on a patient’s health, sometimes even more than other well-known complications. The study aims to develop a better way to predict how patients will do by including nutritional information, using advanced methods to measure changes in nutrients in the body.

People aged 18 to 75 with a confirmed diagnosis of liver cirrhosis and expected to live more than three months may be eligible to join. Participants will be asked to provide information about their nutritional status and health over time. This information will help researchers understand how nutrition relates to cirrhosis outcomes and create a new prediction model to guide better care. If you have liver cirrhosis and are interested, this study might offer an opportunity to contribute to research that could improve future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participants must meet all of the following criteria to be eligible for this study.
• • 1. Willingness and ability to sign the informed consent form.
• • 2. Male or female, aged 18 to 75 years.
• • 3. A diagnosis of liver cirrhosis that meets the reference criteria of the Chinese Society of Hepatology's "Guidelines for the Diagnosis and Treatment of Liver Cirrhosis".
• • 4. An expected survival of over 3 months.
• • 5. Full civil competence.
• Exclusion Criteria:
• • 1. Primary liver cancer diagnosis, or supporting evidence of elevated alpha-fetoprotein (AFP≥100μg/L) for \>3 months, or imaging evidence of hepatic cancer nodules.
• • 2. Malignancy history within 5 years before screening, except for specific cured cancers (e.g., basal cell skin cancer); current or past major illnesses (as defined by the China Insurance Regulatory Commission's 25 critical illnesses) that may affect treatment, assessment, or compliance.
• • 3. Severe pulmonary, cardiac, diabetic, or genetic metabolic diseases.
• • 4. Psychiatric hospitalization, suicide attempts, or temporary disability due to mental illness in the past 5 years.
• • 5. Pregnant or breastfeeding women.
• • 6. Individuals deemed unsuitable by the investigator.