Efficacy of kTMP, a Novel Non-invasive Brain Stimulation Method, for the Treatment of Anhedonia

Launched by MAGNETIC TIDES · Jun 14, 2025

Keywords

ClinConnect Summary

This clinical trial is testing a new, non-invasive treatment called kTMP to help people who have anhedonia, which means they find it hard to enjoy things, often linked to depression. The study aims to see if this brain stimulation method can improve these feelings in adults diagnosed with Major Depressive Disorder (MDD).

To join the study, participants need to be between 21 and 65 years old, have significant anhedonia based on a questionnaire, and have a diagnosis of MDD. The study will not include people with certain other mental health conditions, recent substance abuse, seizure history, or those with metal implants or pacemakers. Pregnant women and people with serious medical problems are also excluded. If eligible, participants will receive the kTMP treatment, which is safe and painless, and the researchers will monitor how well it helps with their symptoms. This study is not recruiting yet, but it hopes to offer a new option for people struggling with depression-related loss of pleasure.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: (1) Patients 21-65 years of age with clinically significant anhedonia, as defined by a SHAPS score of at least 20, and (2) Meet DSM-VTR diagnostic criteria for Major Depressive Disorder.
• • Exclusion Criteria:(1) Reason to anticipate possible hospitalization during the course of the study; (2) Current/history of a psychotic disorder, current manic or mixed episode, meeting the DSM-VTR criteria for bipolar disorder, post-traumatic stress disorder, schizophrenia, at screening, autism spectrum disorders, or mental retardation; (3) Meet DSM-VTR criteria for a substance use disorder within the last year; (4) Current suicidal ideation, suicidal ideation with intent, plan or attempt within the last year, or are considered at significant risk for suicide during the study; (5) Use of any drugs/medications that may interfere/interact with the expected outcomes of the study within 5 half-lives of study participation (see Human Subject section for details); (6) History of seizure; (7) Intracranial expansive process; (8) Pacemaker or any metal implants in head/neck region; (9) Pregnancy; (10) Uncontrolled medical problems including but not limited to severe cardiovascular and cardiopulmonary disease, severe alcohol or drug abuse within the past year; (11) Contraindications for non-invasive brain stimulation or magnetic resonance imaging procedures; (12) Any other condition that in the opinion of the investigator would preclude participation in the study.