Assessing An Oral JAK1 Inhibitor, Golidocitinib, in Patients Who Have Newly Diagnosed Peripheral T-Cell Lymphoma (JACKPOT23)

Launched by SUN YAT-SEN UNIVERSITY · Jun 18, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new medicine called golidocitinib, taken by mouth, to treat people who have just been diagnosed with a type of blood cancer called peripheral T-cell lymphoma (PTCL). The main goal is to see how well this medicine works to stop the cancer from getting worse over two years. The study will also look at what side effects might happen while taking the medicine.

Adults aged 18 and older who have not yet received any treatment for their PTCL may be eligible to join. To join, patients must have a confirmed diagnosis of certain subtypes of PTCL and be healthy enough to take part in the study. Participants will receive the study medicine and be closely monitored by doctors to track how the cancer responds and to check for any side effects. This study is not yet enrolling patients, but it aims to help find better treatments for people newly diagnosed with this type of lymphoma.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female ≥ 18 years old.
• • 2. ECOG performance status 0-2 with no deterioration over the previous 2 weeks.
• • 3. Predicted life expectancy ≥ 12 weeks.
• 4. Patients must have histologically confirmed peripheral T-cell lymphoma. Eligible histological subtypes are restricted to the following:
• • PTCL, not otherwise specified (PTCL, NOS) (the proportion of PTCL-NOS subtype will not exceed 30% of all enrolled)
• • Angioimmunoblastic T-cell lymphoma (AITL)
• • Follicular T cell lymphoma
• • PTCL with T follicular helper (TFH) phenotype
• • 5. Patients must have measurable disease according to the 2014 Lugano classification.
• • 6. Patients must be treatment naïve with no prior systemic treatment for T-cell lymphoma.
• • 7. Adequate bone marrow reserve and organ system functions.
• • 8. Willing to comply with contraceptive restrictions.
• Exclusion Criteria:
• 1. Intervention with any of the following:
• • Any investigational anti-cancer agents or study anti-cancer drugs from a previous clinical study.
• • Any cytotoxic chemotherapy from a previous treatment regimen.
• • Corticosteroids at dosages equivalent to prednisone \> 40 mg/day within 7 days.
• • 2. Major surgery procedure, or significant traumatic injury within 4 weeks.
• • 3. Prior treatment with a JAK or STAT3 inhibitor.
• • 4. Prior treatment with any onco-immunotherapy in 28 days.
• • 5. Live vaccines within 28 days.
• • 6. Patients currently receiving (or unable to stop use at least 14 days prior to receiving the first dose) medications or herbal supplements known to be Potent inhibitors or inducers of CYP3A.
• • 7. Central nervous system or leptomeningeal lymphoma.
• • 8. Past medical history of pneumonitis, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease.
• • 9. Patients with disease condition which requires the treatment of immunosuppressants, biologics, or NSAID.
• • 10. Active infections
• • 11. Clinically significant cardiac disorders or abnormalities. Acute thrombotic diseases within 90 days.
• • 12. Another malignancy within 5 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell carcinoma or nonmelanomatous skin cancer.
• • 13. Gastrointestinal disorders that is inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of golidocitinib.
• • 14. History of hypersensitivity to active or inactive excipients of golidocitinib or drugs with a similar chemical structure or class.
• • 15. Women who are breast feeding or pregnant.