Reset: Enhancing Weight Loss in a Digital Intervention

Launched by STANFORD UNIVERSITY · Jun 15, 2025

Keywords

ClinConnect Summary

This clinical trial, called Reset, is studying different ways to help adults lose weight using a fully digital program. The study focuses on four key eating habits: cutting back on high-calorie, low-nutrition foods (called Red Zone Foods), limiting the times of day when you eat, eating more protein, and eating more fiber. Participants will set goals, track their progress every day, and receive personalized feedback to support these habits. The program lasts 12 weeks, and everything is done remotely, so participants can take part from home using their smartphone and personal scale.

Adults who are overweight or have obesity, live in the U.S., and want to lose weight through lifestyle changes may be eligible. To join, you need to be 18 or older, have a body mass index (BMI) between 25 and 45, and have daily access to a scale, email, and a smartphone. People who are pregnant, recently lost a lot of weight, or are using weight loss medications may not qualify. During the study, participants will weigh themselves daily, complete weekly lessons about healthy eating and physical activity, and fill out surveys at the start, after one month, and at the end of the 12 weeks. The goal is to figure out which combination of these eating habits helps people lose the most weight in a safe and effective way.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • adults (ages 18+ years)
• • body mass index (BMI) 25.0 to 45.0 kg/m\^2
• • smartphone ownership
• • daily access to a personal scale
• • daily access to a personal email account
• • English language proficiency
• • interest in losing weight through behavioral strategies
• • living in the United States
• Exclusion Criteria:
• • concurrent enrollment in another weight management intervention
• • loss of ≥5% body weight in the past 6 months
• • current use of a weight loss or anti-obesity medication
• • prior or planned bariatric surgery in the next 3 months
• • current pregnancy, planned pregnancy in the next 3 months, or recent pregnancy in the past 6 months
• • current breastfeeding or lactating
• • living with someone else participating in the study
• • hospitalization for a mental health condition in the past 12 months
• • inability to engage in moderate forms of physical activity akin to brisk walking
• • if weight loss is contraindicated or might be impacted by a condition (e.g., end stage renal disease, cancer, schizophrenia, dementia) or medication (e.g., steroids, antipsychotics)
• • if an individual would be better suited for a more intensive or different type of intervention based on a health condition (e.g., individuals with history of an eating disorder or cardiovascular event, uncontrolled hypertension, or uncontrolled diabetes mellitus)
• • participation in another weight loss study conducted in Dr. Patel's lab in the past 6 months
• • investigator discretion for safety reasons