Inferior Vena Cava Collapsibility Index and Intradialytic Hypotension

Launched by FIRST AFFILIATED HOSPITAL OF WANNAN MEDICAL COLLEGE · Jun 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a way to predict drops in blood pressure during dialysis, called intradialytic hypotension, which can be a common and uncomfortable problem for people with end-stage kidney disease. The researchers are using ultrasound to look at a large vein in the body called the inferior vena cava (IVC) to see if changes in its size can help identify who might experience these blood pressure drops during their dialysis treatment. The goal is to find a simple, non-invasive test that can help doctors manage dialysis better and keep patients safer.

Adults aged 18 or older who have kidney failure and have been on regular hemodialysis for at least three months may be able to take part, unless they have certain heart problems or other health issues that could affect the results. Participants will have an ultrasound scan of the IVC about one hour into their dialysis session, while their blood pressure is closely monitored throughout. This study involves several hospitals and aims to include about 188 people. If you join, you’ll have this one-time ultrasound during your treatment, and the information gathered could help improve care for people like you in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults aged 18 years or older.
• • Diagnosed with end-stage renal disease (ESRD).
• • Undergoing regular hemodialysis for at least three months.
• Exclusion Criteria:
• • Pregnant or breastfeeding women.
• • Hemodynamically unstable patients or those requiring vasopressor support.
• • Patients with severe cardiac conditions, including congestive heart failure -classified as NYHA Class III-IV or severe valvular disease.
• • Patients with known allergies to dialysis filters.
• • Dialysis sessions terminated for reasons unrelated to hypotension (e.g., technical issues, patient request).
• • Patients who withdraw informed consent during the study.
• • Use of antihypertensive medications during dialysis sessions.
• • Inability to undergo ultrasound assessment due to factors such as severe obesity or wounds obstructing access.