Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

Launched by TAICHUNG VETERANS GENERAL HOSPITAL · Jun 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether taking an oral supplement containing hyaluronic acid, together with standard knee injections of hyaluronic acid, can better relieve symptoms of knee osteoarthritis compared to injections alone. Knee osteoarthritis is a common condition where the cartilage in the knee wears down, causing pain and stiffness. Researchers want to see if adding the oral supplement helps improve pain and function more than the injections by themselves.

To take part, individuals need to be between 60 and 75 years old, have mild to moderate knee osteoarthritis confirmed by X-rays, and show some fluid buildup in the knee joint seen on ultrasound. People with other joint diseases, recent knee injuries, nerve pain, certain brain or spinal conditions, depression, or pregnancy cannot join. Participants will receive either the oral hyaluronic acid supplement or a placebo (a pill without the active ingredient) for three months, along with their usual knee injections. This study is currently recruiting people who meet these criteria to help find better treatment options for knee osteoarthritis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Radiological evidence of osteoarthritis Ahlbäck stage I-III.
• • 2. Had knee effusion at the suprapatellar recess under ultrasonographic examination.
• • 3. Age between 60 and 75 years old.
• Exclusion Criteria:
• • 1. Rheumatological disorders
• • 2. Accidental trauma or fractures involving knees in the past three months
• • 3. Neuropathic pain involving lower limbs
• • 4. Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders.
• • 5. Depression and cognitive problems
• • 6. Pregnancy