Exercise in Hereditary ATTR (ATTRv) Amyloidosis

Launched by UNIVERSITY OF MAIA · Jun 22, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a 12-week exercise program might help people living with Hereditary ATTR (ATTRv) Amyloidosis, a rare genetic condition where abnormal protein builds up in the nerves and organs, causing health problems. The study wants to see if exercising can improve both physical abilities and mental well-being for those affected by this disease.

People who may join the study are adults aged 65 to 74 years old, living in Portugal, who have early to moderate stages of ATTRv Amyloidosis (stage 1 or 2), and are healthy enough to safely participate in exercise. Those who have had a liver transplant within the last 6 months cannot take part. If you join, you’ll follow a supervised exercise routine for 12 weeks, and the researchers will check how this affects your strength, mobility, and mood. This study is currently recruiting participants, so if you or a family member fit these criteria and are interested, it could be a valuable opportunity to explore how staying active might improve quality of life with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ATTRv Amyloidosis patients living in Portugal;
• • Disease stage 1 or 2;
• • No medical contraindication for exercising;
• • Ability to provide informed consent.
• Exclusion Criteria:
• • - Having undergone a liver transplant in the past 6 months.