Pharmacokinetic Study of Topical Phenylephrine

Launched by APPLIED BIOLOGY, INC. · Jun 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a medicine called phenylephrine, when applied directly to the scalp, behaves in the body. Phenylephrine is being looked at here to see if it can help with hair loss caused by chemotherapy or other side effects of chemotherapy. The study is in an early phase, meaning it’s mainly focused on understanding how the body absorbs and processes this medicine when used on the scalp.

Women between the ages of 18 and 55 who are generally healthy may be eligible to participate. To join, participants need to have a scalp that is healthy and free from irritation or damage, and they should have a body weight within a certain range. People with heart problems, scalp infections, or allergies to the medicine won’t be able to join. During the study, participants will need to avoid using other products on their scalp. This trial is not yet recruiting, but once it starts, it will help researchers learn important information about the safety and effects of topical phenylephrine for women dealing with hair loss related to chemotherapy.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy females, age 18-55
• • BMI: 18-30 kg/m²
• • Fitzpatrick Skin Types I-IV (to standardize absorption risk)
• • Scalp free from irritation, dermatologic disease, or damage
• • Able to refrain from using other topical scalp products
• Exclusion Criteria:
• • History of cardiovascular disease, hypertension, or arrhythmia
• • Scalp infections, wounds, or significant hair loss
• • Recent use of medications that interfere with CYP enzymes or adrenergic systems
• • Known sensitivity to phenylephrine or ethanol
• • Positive drug screen or abnormal ECG at screening