Fractional CO₂ Laser or 40% Urea With Topical Fluconazole Microemulsion in Onychomycosis

Launched by ASSIUT UNIVERSITY · Jun 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to treat onychomycosis, which is a fungal infection of the nails. The study compares two treatments used alongside a special antifungal medicine called topical fluconazole microemulsion. One treatment uses a fractional CO₂ laser, which is a type of light therapy to help the medicine work better, while the other uses 40% urea, a substance that softens and removes the infected nail layers.

People who might be eligible to join this study are adults with confirmed fungal nail infections who haven’t used antifungal creams in the past month or oral antifungal medicines in the past three months. Pregnant or breastfeeding women, those with certain nail conditions like psoriasis, or anyone allergic to the treatments won’t be able to participate. If you join, you can expect to receive one of the two treatments along with the topical fluconazole and have your progress monitored to see which method is safer and more effective at clearing the infection. The study is not yet recruiting participants but may be an option for those looking for new treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinically and mycologically confirmed onychomycosis
• • No topical antifungal use in the past 1 month
• • No systemic antifungal use in the past 3 months
• Exclusion Criteria:
• • pregnancy or lactation
• • Nail disorders such as psoriasis, eczema, lichen planus
• • patients have a known allergy to any of the study treatments