Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia

Launched by IRCCS SAN RAFFAELE · Jun 13, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain blood cells and clots (called thrombi) are involved in strokes caused by blockages in large blood vessels in the brain. Researchers will collect and examine blood and clot samples from patients who are undergoing a procedure called mechanical thrombectomy, which is used to remove these blockages. The goal is to better understand how these clots form and behave, why some strokes don’t respond well to current medicines, and to find new ways to treat or prevent strokes in the future.

Adults aged 18 and older who come to the hospital with symptoms of a stroke or related risk factors—such as irregular heartbeat, infections, or narrowing of neck arteries—and who are receiving treatments like clot-removal procedures or clot-busting medicines may be eligible to join. Participants will be asked for consent to use their blood and clot samples for research, either directly or through approved procedures if they are unconscious. People who are pregnant, breastfeeding, or have certain autoimmune diseases won’t be able to take part. This study is not yet recruiting patients but aims to help improve stroke care by learning more about the causes and treatment of these serious events.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years.
• * Presentation to the emergency department with symptoms and/or signs suggestive of:
• • An acute cerebrovascular event
• • Stroke mimics
• • Stroke-related risk factors (e.g., atrial fibrillation, endocarditis, significant internal carotid stenosis, neoplasms, systemic infections)
• * Undergoing one of the following treatments:
• • Mechanical thrombectomy
• • Intravenous thrombolysis
• • Standard medical therapy
• * Provision of informed consent, either:
• • Directly from the conscious patient
• • Via appropriate procedures for unconscious patients
• Exclusion Criteria:
• • Pregnancy or breastfeeding
• • Presence of a known autoimmune disease that could interfere with the interpretation of biomarker analyses