Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass

Launched by ALEXANDRIA UNIVERSITY · Jun 14, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how certain measurements taken during heart surgery called coronary artery bypass grafting (CABG) might help predict how well patients recover afterward. Specifically, the researchers want to see if levels of a substance called lactate in the blood, as well as oxygen levels in a central vein, can signal the risk of complications or problems after surgery. These measurements would be taken while the patient is on a heart-lung machine during surgery and when they arrive in the intensive care unit (ICU).

The study is looking for adults 18 years and older who are scheduled for planned CABG surgery using the heart-lung machine. People with certain health conditions, like very low blood counts, severe heart weakness, kidney or liver problems, lung diseases, previous strokes, or those needing repeat heart surgery, would not be eligible. If you take part, your medical team will monitor your blood lactate and oxygen levels closely during and after surgery to see if these can help predict your recovery. This trial has not started recruiting yet, but it aims to improve how doctors identify patients who might need extra care after heart surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• cardiac surgical patients who will undergo isolated elective CABG and fulfill these criteria:
• • 1. Aged 18 years or above.
• • 2. Operated with cardiopulmonary bypass.
• Exclusion Criteria:
• • 1. Preoperative lactate level greater than 3 mmol/l.
• • 2. Redo surgery.
• • 3. If the patient will be reoperated during the study time.
• • 4. Preoperative hemoglobin level less than 10 mg/dl.
• • 5. Ejection fraction (EF) of \<30%.
• • 6. Renal impairment.
• • 7. Liver impairment.
• • 8. History of stroke and significant carotid artery stenosis.
• • 9. Chronic obstructive or restrictive lung disease.