Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
Launched by AIN SHAMS UNIVERSITY · Jun 15, 2025
Trial Information
Current as of July 22, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
A. Preoperative Settings:
Patients will undergo standard pre-anesthetic assessment, including review of medical history, fasting status, and laboratory investigations. Eligibility will be confirmed based on inclusion and exclusion criteria. After obtaining informed consent, patients will be randomly assigned into two groups using a computer-generated randomization table and sealed envelopes.
B. Intraoperative and Postoperative Settings:
All patients will receive standardized general anesthesia with continuous monitoring. Following completion of surgery and while still under anesthesia, t...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age between 30 and 60 years
- • American Society of Anesthesiologists (ASA) physical status II
- • Diagnosed hypertension
- • Scheduled for elective craniotomy under general anesthesia
- • Able and willing to provide informed consent
- Exclusion Criteria:
- • ASA physical status III or IV
- • Uncontrolled comorbidities (e.g., diabetes mellitus)
- • Coagulopathy or current use of anticoagulant or antiplatelet therapy
- • Known allergy or hypersensitivity to dexmedetomidine or labetalol
- • Emergency craniotomy
- • Pregnant or breastfeeding women
- • Patients with a history of severe cardiac arrhythmias
- • Inability to provide informed consent
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, , Egypt
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported