Bronchial Response to Exercise After Double Lung Transplantation

Launched by CHANG GUNG MEMORIAL HOSPITAL · Jun 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the airways (the tubes that carry air in and out of the lungs) respond to exercise in people who have had both lungs replaced through a double lung transplant. The researchers want to see if there is a difference in breathing difficulty during two different exercise times—5 minutes and 15 minutes—and how this might relate to feelings of breathlessness.

To take part, you need to have had a double lung transplant at least three months ago. The study is open to all adults, but people with asthma, significant lung problems, or recent infections or transplant rejection won’t be eligible. Participants will be asked to do some exercise tests while the researchers measure how their airways react. This study is still recruiting, and it aims to help doctors better understand breathing challenges after lung transplant and improve care for transplant recipients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Received double lung transplantation
• • 2. ≥ 3 months post-transplant
• Exclusion Criteria:
• • 1. Diagnosis of asthma
• • 2. Significant airflow limitation (≤50% FEV1 predicted)
• • 3. Inability to cooperate with the required tests and measurements
• • 4. Recent infection or rejection within 1 month
• • 5. Exercise contraindication (e.g., recent heart attack or stroke within 3 months, uncontrolled hypertension, known aortic aneurysm, unstable cardiac ischemia, malignant arrhythmias)