Effect of Sevoflurane on Sweat Threshold in Children of Different Ages

Launched by SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY · Jun 16, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a common anesthesia medicine called sevoflurane affects children’s body temperature control during surgery. When children have surgery, their body temperature can drop too low (called hypothermia), which can make it harder for them to recover and may cause other health problems. The study wants to understand how sevoflurane impacts the point at which children start to sweat, an important way the body regulates temperature, and how this might differ between younger and older children. This information could help doctors better manage children’s body temperature during surgery to keep them safe and comfortable.

Children aged from newborn up to 12 years old who are healthy enough for surgery and are scheduled for planned lower-body operations lasting at least an hour may be eligible to join. Children must have a normal weight for their age and no serious medical conditions like thyroid problems or issues with the nervous system. If you agree to take part, your child will have their temperature carefully monitored during surgery using a safe probe inserted into the esophagus (the tube connecting the mouth to the stomach). The study has not started recruiting yet, but it aims to improve how anesthesia care is given to children by better understanding how their bodies handle temperature changes during surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age: 0-12 years old;
• • 2. American Society of Anesthesiologists physical status I or II;
• • 3. Weight within the normal range and body-mass index (BMI) for age between the 25th and 85th percentiles;
• • 4. scheduled elective lower-body surgery under general anesthesia, expected to last at least 1 hour.
• Exclusion Criteria:
• • 1. The guardian of the child refused to participate in the study;
• • 2. Operations involving extensive incisions, such as massive debridement or other operations requiring removal of large amounts of tissue;
• • 3. Contraindications to esophageal temperature probe insertion (e.g., esophageal varices, congenital anomalies);
• • 4. Thyroid dysfunction or autonomic dysfunction;
• • 5. Premature infants (≤1 year old).