Clinical Trial of PCSK9 Inhibitor and Statin Treatment for Carotid Artery Stenosis

Launched by CHANGHAI HOSPITAL · Jun 23, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how well a combination of two types of medicines—PCSK9 inhibitors and statins—works to treat people with carotid artery stenosis. This condition happens when the arteries in the neck, which supply blood to the brain, become narrowed due to plaque buildup. The trial will look at whether these medicines can help reduce the narrowing and lower the risk of future problems like stroke in people who have mild to moderate narrowing but no symptoms and don’t need surgery right now.

To join the trial, participants need to be adults (18 years or older) with mild to moderate narrowing of the carotid artery confirmed by imaging tests, and they should be able to live independently with no major disabilities. People with certain other health problems, recent strokes or heart procedures, or who are pregnant won’t be eligible. Those who take part will be randomly assigned to receive the medication and will be followed over time to see how well the treatment works. The trial is still not recruiting participants, but it aims to help improve care for people with this artery condition through careful monitoring and treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Clinical inclusion criteria:
• • 1. Age ≥ 18 years.
• • 2. Asymptomatic mild-to-moderate carotid artery stenosis confirmed by CTA, MRA, ultrasound, or DSA, with no anticipated need for surgical intervention.
• • 3. Modified Rankin Scale (mRS) score ≤ 2
• • 4. Signed informed consent form obtained from the subject
• Ultrasound Inclusion Criteria:
• • Carotid ultrasound showing a plaque burden rate ≥30% at the most stenotic cross-sectional site of the carotid artery (common carotid artery or proximal C1 segment of the internal carotid artery).
• Exclusion Criteria:
• • 1. Non-atherosclerotic carotid stenosis, including arterial dissection, Takayasu arteritis, radiation-induced vasculopathy, fibromuscular dysplasia, neurofibromatosis, suspected vasospasm, or recanalized vascular embolism.
• • 2. Known cardioembolic sources: mitral stenosis, mechanical heart valve, infective endocarditis, intracardiac thrombus/vegetation, myocardial infarction within 3 months, dilated cardiomyopathy, chronic/paroxysmal atrial fibrillation. (Confound ASCVD outcome assessment.)
• • 3. History of cerebrovascular, coronary, or peripheral arterial endovascular intervention within 30 days before enrollment or anticipated surgery within the next 6 months.
• • 4. History of ischemic stroke, transient ischemic attack (TIA), or intracranial hemorrhage (parenchymal, subarachnoid, subdural, or epidural) before enrollment.
• • 5. Pre-existing intracranial tumor, cerebral aneurysm, or arteriovenous malformation.
• • 6. History of thromboembolic diseases (pulmonary embolism, mesenteric embolism, lower limb arterial embolism) or coronary atherosclerotic heart disease.
• • 7. Severe neurological deficits impairing independent living; diagnosed dementia/psychiatric disorders interfering with follow-up; or life expectancy \<3 years due to other conditions.
• • 8. Severe/unstable comorbidities: Severe heart failure (NYHA Class III/IV or LVEF \<30%), Renal failure (serum creatinine \>264 μmol/L or creatinine clearance \<0.6 mL/s), Severe hepatic dysfunction (ALT/AST \>3× upper limit of normal), CK \>5× upper limit of normal, Active malignancy.
• • 9. Use of PCSK9 inhibitors or CETP inhibitors within 24 weeks before enrollment.
• • 10. The subjects have taken strong inhibitor drugs of cytochrome P-450 3A4 (including: adagrasib, atazanavir, ceritinib, clarithromycin, darunavir, idelalisib, indinavir, itraconazole, ketoconazole, levonorgestrel, lonafarnib, lopinavir, mifepristone, nefazodone, nelfinavir, nirmatrelvir/ritonavir, Viekira Pak (ombitasvir, paritaprevir, and ritonavir tablets), mbitasvir/paritaprevir/ritonavir and dasabuvir, posaconazole, co-formulations containing ritonavir and ritonavir itself, saquinavir, erythromycin, tucatinib, voriconazole) within one month before randomization, or may require such drugs during the study period.
• • 11. Pregnancy or lactation.
• • 12. Concurrent participation in another trial that may affect outcome assessment.
• • 13. Other situations that the investigator believes may cause significant harm to the subjects if they participate in this trial.
• • 14. Situations where the investigator believes there are other vascular lesions that may lead to short - term ischemic events and surgeries.