The Impact of Different Sedation Regimens on Hemodynamics in Patients Undergoing Mechanical Ventilation With Shock

Launched by PEKING UNIVERSITY PEOPLE'S HOSPITAL · Jun 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how different ways of calming (sedating) patients on breathing machines affect their heart and blood flow. When patients are very sick and need help breathing through a tube, they often feel uncomfortable or restless, so doctors give them medicine to help them relax. But these medicines can sometimes cause problems with blood pressure and blood flow, which can make recovery harder. This study aims to find the best approach to sedation that keeps patients comfortable while also protecting their heart and circulation.

Adults who are very sick with low blood pressure (shock) and have just been placed on a breathing machine with a tube in their windpipe may be able to join. Participants will receive different sedation plans, and the researchers will carefully watch how these affect their heart and blood flow. The study will help doctors understand which sedation methods work best to keep patients safe and comfortable in the intensive care unit. Pregnant people, those with certain brain or spinal injuries, or those expected to live less than two days won’t be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years; 2. Receiving invasive mechanical ventilation, with endotracheal intubation performed \<12 hours before enrollment; 3. Patient requiring sedative and analgesic medications; 4. Hemodynamic instability: Hypotension (systolic blood pressure \<90 mmHg or mean arterial pressure \<65 mmHg) occurring within 6 hours before intubation to 6 hours after intubation, requiring continuous vasoactive medication therapy for \>1 hour.
• Exclusion Criteria:
• • 1. Pregnant or breastfeeding patients; 2. Patients with confirmed or suspected acute primary brain pathology (e.g., traumatic brain injury, intracranial hemorrhage, stroke, hypoxic brain injury); 3. Patients with confirmed or suspected spinal cord injury or other pathologies likely to cause permanent or prolonged weakness; 4. Patients with known allergy to the analgesic, sedative, or vasoactive medications used in the study protocol; 5. Patients receiving palliative care or with an expected survival of ≤48 hours; 6. Patients previously enrolled in this study