Refining mUltiple Artificial intelliGence strateGies for Automatic Pain Assessment Investigations: RUGGI Study

Launched by VALENTINA CERRONE · Jun 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying new ways to use artificial intelligence (AI) to automatically assess chronic pain, which includes long-lasting pain from conditions like cancer, nerve damage, or other ongoing health problems. The goal is to create computer models that can recognize and measure pain by looking at different types of information, such as brain activity, heart rate, skin responses, and facial expressions. This could help doctors better understand and manage pain without relying only on patient descriptions.

Adults who have had chronic pain for more than three months—whether from conditions like fibromyalgia, arthritis, or cancer-related pain—may be eligible to join. Participants will take part in several non-invasive tests, including wearing sensors and answering questionnaires about their pain and quality of life. These procedures are safe and designed to collect detailed information to improve AI tools for pain assessment. The study is open to all adults who can give informed consent and do not have certain psychiatric conditions or substance abuse issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (≥18 years old) with chronic pain, defined according to IASP and ICD-11 as pain that persists or recurs for more than three months.
• * Diagnosed with either:
• • Chronic primary pain (e.g., fibromyalgia, irritable bowel syndrome, chronic headaches)
• • Chronic secondary non-cancer pain (e.g., low back pain, osteoarthritis, post-surgical pain)
• • Chronic cancer-related pain (due to cancer or its treatment)
• • Ability to understand the study procedures and provide written informed consent.
• Exclusion Criteria:
• • Current treatment with psychotropic drugs or presence of active psychiatric disorders (e.g., psychosis, major depression).
• • Known history of alcohol or substance abuse.
• • Pregnancy or breastfeeding.
• • Age under 18 years.
• • Inability to provide informed consent (e.g., due to cognitive impairment).