EVALUATION OF NEUTROPHIL FLUORESCENCE IN PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION ASSOCIATED WITH SEPTIC SHOCK

Launched by UNIVERSITY HOSPITAL, STRASBOURG, FRANCE · Jun 17, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help diagnose a serious condition called disseminated intravascular coagulation (DIC) that can happen in patients with septic shock—a life-threatening response to infection. The researchers are looking at whether measuring a special glow (called fluorescence) in certain white blood cells (neutrophils) can reliably and quickly detect DIC. Their goal is to find the right level of this glow that correctly identifies at least 90% of patients with this condition, which could help doctors diagnose and treat it sooner.

Adults 18 years and older who are in the intensive care unit with septic shock may be eligible to participate, as long as they don’t have certain other health issues like severe liver disease, very low white blood cell counts, or are pregnant or breastfeeding. Patients need to be able to give consent, or if they can’t, a family member may provide it, or emergency procedures may be used if no family is available. Participants can expect tests that measure neutrophil fluorescence, which is a blood test, to help the researchers understand if this method works well. This study is not yet recruiting, but it aims to improve early diagnosis of DIC in very sick patients, potentially leading to better care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female ≥ 18 years of age
• • Patient admitted to intensive care for septic shock
• • Patient affiliated to a social security scheme or entitled to it
• • Non-opposition by the patient or a relative in the event that the patient is not in a state to express his or her consent or inclusion in an emergency procedure in the event that the patient is not in a state to express his or her opinion and no relative of the patient can be reached.
• Exclusion Criteria:
• • Dying patient on the day of inclusion
• • Cirrhosis Child Pugh C
• • Neutropenia (\<500 mm3)
• • Patient under judicial protection
• • Patient under guardianship or curatorship
• • Pregnancy
• • Breastfeeding