EVOLUTION OF D-DIMER AS A MARKER OF BLEEDING RISK ON ECMO

Launched by UNIVERSITY HOSPITAL, STRASBOURG, FRANCE · Jun 17, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at whether changes in a blood test called D-dimer can help predict the risk of serious bleeding in patients who are receiving ECMO treatment. ECMO is a special life-support machine used in intensive care to help people with very severe heart or lung problems. While ECMO can save lives, it can also increase the chance of dangerous bleeding. The study aims to see if monitoring D-dimer levels over time can help doctors better understand and manage this risk.

Adults aged 18 and older who are in intensive care and have just started ECMO treatment (within the last 24 hours) might be eligible to participate. People who have certain conditions like recent heart surgery, bleeding disorders, or who are pregnant or breastfeeding would not be included. If you take part, your medical team will watch how your D-dimer levels change while you’re on ECMO to see if these changes relate to bleeding risks. This information could help improve care and safety for future patients on ECMO.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female ≥ 18 years of age
• • Hospitalized patient in intensive care
• • Implementation of a VV or VA ECMO for less than 24 hours
• • Patient affiliated to a social protection health insurance scheme
• • Non-opposition by the patient or a relative in the event that the patient is not in a state to express his or her non-opposition or inclusion in an emergency procedure in the event that the patient is not in a state to express his or her non-opposition and no relative of the patient can be reached.
• Exclusion Criteria:
• • Patient on veno-arterial ECMO after cardiac, cardiopulmonary surgery or after placement of a left or biventricular cardiac assist device
• • Congenital hemostasis disorder or anatomical abnormality predisposing to bleeding
• • Dying patient on the day of inclusion
• • Patient under judicial protection
• • Patient under guardianship or curatorship
• • Pregnancy
• • Breastfeeding