Hemodynamic Effects of Intradermal Methylene Blue During Breast Surgery Under General Anesthesia

Launched by DR ABDURRAHMAN YURTASLAN ANKARA ONCOLOGY TRAINING AND RESEARCH HOSPITAL · Jun 19, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how a dye called methylene blue, used during breast cancer surgery, affects blood pressure and heart function while patients are under general anesthesia. Methylene blue helps surgeons find important lymph nodes during surgery, but doctors want to understand if it might cause any changes in blood flow or low blood pressure during the operation. By carefully monitoring heart rate, blood pressure, and oxygen levels before and after the dye is given, the study aims to see if methylene blue is safe and how it might affect patients’ stability during surgery.

Women between 18 and 70 years old who are scheduled for planned breast surgery—such as a mastectomy, lumpectomy, or a sentinel lymph node biopsy—and who will receive methylene blue as part of their procedure may be eligible to join. Participants will be closely observed during their surgery, with no changes to their usual care besides the extra monitoring. The study excludes women who are allergic to methylene blue, have serious heart problems, or are pregnant. The goal is to improve understanding of how this dye works during surgery to help make anesthesia care safer for future patients.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female patients aged 18 to 70 years Scheduled for elective breast surgery (mastectomy, lumpectomy, or sentinel lymph node biopsy) Planned use of intradermal methylene blue for sentinel lymph node mapping Provided written informed consent
• Exclusion Criteria:
• • Known allergy or hypersensitivity to methylene blue or other dyes Presence of severe cardiovascular disease Pregnancy Incomplete or missing data records