Comparison of Methods for Removing Large Benign Broad-based Epithelial Neoplasms of the Colon: ESD and EMR.

Launched by PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY · Jun 19, 2025

Keywords

ClinConnect Summary

Objective of the study: to prospectively compare the immediate, immediate and remote results of endoscopic mucosal resection through an endoscope and endoscopic submucosal dissection performed for non-invasive large-sized (20 mm or more) broad-based epithelial lesions of the colon.

Study objectives:

1. To evaluate the accuracy of ultra-high-resolution colonoscopy in white, ultra-clear and narrow-spectrum light with magnification in predicting the histological structure and risks of invasion of large-sized broad-based epithelial lesions of the colon.
2. To conduct a comparative assessment ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient with benign non-invasive epithelial formations of the colon on a broad base (Is and II types), 20-60 mm in size
• • Age ≥ 18 years.
• • Signed informed voluntary consent for colonoscopy and removal of formations using the studied methods of EMR and ESD
• Exclusion Criteria:
• • . More than one large epithelial lesion on a broad base
• • Colon lesion less than 20 mm and more than 60 mm
• • Recurrent lesion.
• • Reasonable suspicion of an invasive lesion (cancer), including one with submucosal invasion based on the results of preoperative assessment (NICE - 3; JNET - 3; Kudo - Vn).
• • Presence of widespread malignant tumour in any part of the colon.
• • Use of other methods of endoscopic lesion removal.
• • IBD.
• • Infectious disease requiring systemic therapy
• • Patient on haemodialysis
• • Uncorrectable coagulopathy (INR\> 1.5), inability to discontinue antithrombotic drugs.
• • Refusal to participate in the study. 12. General contraindications to endoscopic examination.