Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway

Launched by YI SHAO · Jun 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how the bacteria living in the gut and certain substances made from an amino acid called tryptophan might be different in people who have kidney stones compared to those who don’t. Researchers are especially interested in a type of bacteria called Lactobacillus salivarius and in two specific tryptophan-related substances found in the blood. They also want to see if changes in weather, like temperature and humidity, affect these gut bacteria and substances. Understanding these differences could help explain why some people develop kidney stones.

Adults aged 18 and older who either have kidney stones diagnosed by imaging tests or are healthy without any history of kidney stones may be able to join. Participants will be asked to provide stool (poop) and blood samples for analysis. People who recently took antibiotics or have certain health problems, like infections or serious diseases, won’t be able to join. The study is not yet recruiting, but if you participate, you can expect to help researchers learn more about the connection between gut health and kidney stones, which could lead to better prevention or treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Inclusion criteria for patients with kidney stones
• • Age\>=18 years;
• • Diagnosed with kidney stones by ultrasound, CT or urography;
• • Willing to provide stool samples and serum samples for study;
• • No history of antimicrobial use in the past 3 months;
• • Signed and dated informed consent indicating that the patient or his/her legal representative is fully informed of the study-related information and agrees to participate.
• • Inclusion criteria for the healthy control group
• • Age\>=18 years;
• • No history of kidney stones and family history;
• • Imaging examination (such as abdominal ultrasound) showed no kidney stones;
• • Willing to provide stool samples and serum samples for research;
• • No history of antibiotic use in the past 3 months;
• • Signed and dated informed consent indicating that the volunteer is fully informed about the study-related information and agrees to participate.
• Exclusion Criteria:
• • Use of antimicrobials or probiotics within the past 3 months;
• • Presence of active urinary tract infection;
• • Presence of other serious systemic diseases, such as hepatic or renal insufficiency, cardiac or pulmonary diseases, malignant tumors, and immunodeficiency states;
• • Congenital urinary tract abnormalities;
• • Previous history of kidney transplantation or urinary diversion surgery;
• • Pregnant or lactating women;
• • Presence of chronic intestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, etc.;
• • Inability to provide samples or complete follow-up according to the research protocol;
• • Participation in other clinical studies within the past 3 months;
• • Other conditions deemed unsuitable for participation in this study by the researcher.