Measuring Acute Drug Demand in Humans II

Launched by JOHNS HOPKINS UNIVERSITY · Jun 20, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how different drugs and combinations of drugs affect mood, pain, and how well people perform certain tasks. The goal is to better understand the immediate effects these substances have on the body and mind. This study is currently not accepting participants but plans to include healthy adults between the ages of 18 and 55 who have normal vital signs and are willing to give their informed consent to join.

If you take part, you can expect to be carefully screened to make sure you meet the health requirements and do not have any conditions that might make the study unsafe for you. People who are dependent on alcohol or certain medications, have serious health or mental health issues, are pregnant or breastfeeding, or are currently in other drug studies will not be eligible to participate. The study team will monitor you closely to ensure your safety while assessing how the drugs affect your mood, pain levels, and performance. This research could help improve future treatments and our understanding of how these drugs work in the body.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18-55 years
• • 2. Vital signs in normal range as reviewed by study medical team
• • 3. Person is willing and able to provide informed consent
• Exclusion Criteria:
• • 1. Evidence of physical dependence on alcohol or benzodiazepines based on tolerance and withdrawal upon cessation of use of alcohol or benzodiazepines reported in the Mini-International Neuropsychiatric Interview (MINI) as well as clinical interviews by medical staff during H\&P.
• • 2. Seeking treatment for alcohol or substance use
• • 3. Have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity
• • 4. Active hepatic disease or abnormal liver function tests
• • 5. Current major depressive disorder or suicidality
• • 6. Are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding. People of childbearing potential will be asked to ensure, and/or the partner use effective forms of contraception for the duration of the study and excluded if unable.
• • 7. Are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.
• • 8. Contraindications or allergies to study medications
• • 9. Evidence of recent illicit substance use (i.e., positive urinalysis) at screening for drugs other than cannabis
• • 10. Seizure disorder or traumatic brain injury (TBI)
• • 11. Taking medications known to interact with study medications