Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Propofol Anesthesia

Launched by TAMAS VEGH, MD · Jun 27, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at how safe and effective a medicine called Sugammadex is for reversing muscle relaxation caused by certain drugs used during general anesthesia. When patients have surgery, muscle relaxants like Pipecuronium or Rocuronium are often given to help with breathing and surgery conditions, but these muscles need to work again properly after the operation. This study will carefully monitor how quickly and safely Sugammadex can reverse the muscle relaxation, making sure patients recover muscle strength without any leftover weakness or allergic reactions.

The study will include about 80 adult patients aged 18 to 65 who are having planned general or brain surgery lasting at least 40 minutes and requiring a breathing tube. Participants should be generally healthy with a normal body weight and no serious muscle, liver, or kidney problems. During the surgery, patients will receive standard monitoring to track their vital signs and muscle function, and after surgery, doctors will check to ensure the muscle relaxants have fully worn off. This study aims to provide clear information about the safety and recovery process when using these muscle relaxants and Sugammadex, helping improve care for patients undergoing anesthesia.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 80 adult general surgery, neurosurgery patients were recruited in our study after giving an informed written consent to participate in the studies;
• • Age: between 18-65 years;
• • ASA score: 1-3;
• • BMI 18.5-25 (normal body weight);
• • Males and females were recruited in an equal ratio;
• • Minimal surgical time of at least ≥ 40 minutes;
• • Procedures requiring endotracheal intubation
• Exclusion Criteria:
• • Diseases affecting neuromuscular function (myopathies, severe liver and kidney failure);
• • Drugs affecting neuromuscular function (magnesium, aminoglycosides);
• • Difficult airway, or anticipated difficult intubation;
• • Pregnancy (a pregnancy test is performed in women of childbearing age to rule out pregnancy);
• • Breast-feeding;
• • Acute surgery;
• • COPD
• • Glaucoma
• • History of previous allergic/anaphylactic reactions