A Clinical Study of How Coffee and Tea Affect Enlicitide in Healthy Volunteers (MK-0616-040)

Launched by MERCK SHARP & DOHME LLC · Jun 26, 2025

Keywords

ClinConnect Summary

This clinical trial is studying how a medicine called enlicitide behaves in the body when taken with coffee or tea. The researchers want to see if drinking coffee or tea changes the amount of enlicitide in the blood compared to taking it with just water. This study will help us understand if coffee or tea affects how the medicine works.

The study is looking for healthy adults who do not smoke and who regularly drink at least one cup of caffeinated coffee or tea each day, depending on which part of the study they join. People with certain health problems, especially those affecting digestion or with past stomach surgeries, cannot join. Participants will take enlicitide along with their usual coffee, tea, or water, and the researchers will measure the medicine levels in their blood over time. This study is just beginning and is open to adults of all genders who meet the health and drinking habits described.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• The key inclusion criteria include but are not limited to the following:
• • Is in good health
• • Is a non-smoker for at least 3 months prior to study entry
• • Part 1 only: Consumes at least 1 cup of caffeinated coffee per day
• • Part 2 only: Consumes at least 1 cup of caffeinated tea per day
• Exclusion Criteria:
• The key exclusion criteria include but are not limited to the following:
• • Has a history or presence of clinically significant medical or psychiatric condition or disease
• • History of gastrointestinal disease which might affect food and drug absorption, or has had gastric bypass or similar surgery.