Effect of Bilateral vs. Unilateral Alveolar Recruitment on Gas Exchange in Lung Resection

Launched by YONSEI UNIVERSITY · Jun 23, 2025

Keywords

ClinConnect Summary

This clinical trial is looking at two different ways to help improve breathing during lung surgery for patients with lung cancer. When one lung is temporarily turned off to allow the surgeon to work (called one-lung ventilation), it can sometimes cause parts of the lung to collapse, making it harder for the patient to get enough oxygen. The study compares two techniques called alveolar recruitment maneuvers (ARMs), which help reopen the lung areas and improve oxygen flow. One method treats both lungs before surgery starts (bilateral ARM), while the other treats only the lung that will keep working during surgery (unilateral ARM). The goal is to find out which method helps patients breathe better during the operation and causes fewer complications afterward.

Adults between 20 and 80 years old who are scheduled for minimally invasive lung surgery and are generally healthy enough for surgery (with certain health classifications) may be able to join this study. People with severe heart problems, certain lung conditions, or those already needing oxygen or breathing machines before surgery would not qualify. If you participate, the doctors will carefully monitor your lung function during surgery and compare the effects of the two ARM methods. The study has not started enrolling patients yet, but it hopes to help improve care and safety for future lung surgery patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • -Adult patients aged 20 to 80 years scheduled for thoracoscopic lung resection.
• • American Society of Anesthesiologists (ASA) physical status classification of I to III.
• Exclusion Criteria:
• • Anticipated duration of one-lung ventilation (OLV) less than 1 hour.
• • Diagnosis of heart failure.
• • History of pneumothorax or radiologic evidence of pulmonary blebs or bullae prior to surgery.
• • Patients receiving supplemental oxygen therapy or mechanical ventilation prior to surgery.
• • Dropout Criteria
• • Actual duration of OLV less than 1 hour.
• • Surgery is canceled or converted to an open thoracotomy or another surgical approach.
• • Inability to maintain peripheral oxygen saturation ≥90% despite adjustments in inspired oxygen fraction.
• • Inability to maintain ventilator settings due to extensive pulmonary adhesions.