Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke

Launched by HOSPITAL DAS CLÍNICAS DE RIBEIRÃO PRETO · Jun 21, 2025

Keywords

ClinConnect Summary

This clinical trial is studying whether using a treatment called continuous positive airway pressure (CPAP) early on can help people recover better after an ischemic stroke—a type of stroke caused by a blockage in the blood flow to the brain—who also have obstructive sleep apnea (a condition where breathing stops and starts during sleep). The goal is to see if treating sleep apnea soon after a stroke can improve how well patients regain their abilities and function.

People who may be eligible for this study are adults between 18 and 80 years old who have had a recent ischemic stroke in certain areas of the brain and show moderate stroke symptoms. To join, participants must be admitted to the hospital within 12 hours of stroke symptoms starting and not have had a previous stroke or serious health conditions that could affect the study. If chosen, participants will receive CPAP treatment early after their stroke and will be closely monitored to see how their recovery progresses. It’s important to know that some people won’t qualify—such as those already using CPAP, those with severe other illnesses, or those unable to complete follow-up visits. This study is currently looking for participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories
• • Aged 18 to 80 years
• • Symptom onset or symptom recognition to admission \< 12 hours
• • NIHSS score ≥ 4 and ≤ 20 at enrollment
• • Signed informed consent form obtained from the participant or their legal representative
• Exclusion Criteria:
• • Prior stroke
• • Previous diagnosis of OSA with current CPAP use or previously failed CPAP
• • Pre-stroke disability (mRS \> 1)
• • Coma or stupor
• • Orotracheal intubation
• • Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure)
• • Psychomotor agitation
• • High likelihood of neurosurgical intervention within the first 48 hours
• • Oxygen therapy \>2 L/min
• • Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions)
• • Chronic alcohol or drug use with high risk of withdrawal during hospitalization
• • Pregnant or suspected pregnant women
• • Inability to complete follow-up for any reason
• • Any contraindication to CPAP use