Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)

Launched by ESRA DAĞCI · Jun 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying the best way to clean bacteria from root canals during root-canal treatment in adults who have infections or dead tissue in their premolar teeth (the teeth just behind your front teeth). Researchers want to find out if using a natural solution called chitosan alone, or combined with other common cleaning liquids, removes more bacteria inside the tooth. They will compare three groups: one using only chitosan, one using sodium hypochlorite followed by chitosan, and one using sodium hypochlorite followed by EDTA, to see which method works best.

Adults between about 18 and 74 years old with a specific type of infected lower premolar tooth may be eligible if they are generally healthy, haven’t had antibiotics recently, and their tooth doesn’t have previous root-canal treatment or other complications. Participants will have two dental visits: the first to receive the root-canal treatment and bacterial testing, which is quick and painless, and the second about a week later for a check-up and final filling. They will also keep track of any pain or discomfort for a few days after treatment. The procedures are routine, there’s no cost to join, and anyone can leave the study at any time or ask questions along the way.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who agreed to participate in the study
• • Systemically healthy patient
• • Mandibular premolar teeth
• • Teeth that respond negatively to thermal tests and EPT
• • Patients who have not used antibiotics for at least 2 weeks
• Exclusion Criteria:
• • Teeth with previous primary root-canal treatment
• • Pregnant patients
• • Severely curved roots (\>25° curvature)
• • Canals with instrument separation during preparation
• • Calcified (obliterated) canals