TO DETERMINE THE EFFECT OF ALLOGRAFT AND iPRF WITH OR WITHOUT COLLAGEN MEMBRANE ON HEALING OF APICOMARGINAL DEFECTS

Launched by POSTGRADUATE INSTITUTE OF DENTAL SCIENCES ROHTAK · Jun 24, 2025

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help heal a specific dental problem called apicomarginal defects, which happen when there is damage around the tip of a tooth’s root and the surrounding bone. The researchers want to see how well a combination of bone graft material (allograft) and a special blood product (iPRF) works to heal these defects, both with and without using an additional protective layer called a collagen membrane. This could help improve healing after dental surgery in people who have had ongoing infections or issues despite previous root canal treatments.

People who might be eligible for this study are adults aged 18 and older who have a persistent infection at the tip of a tooth’s root that hasn’t healed properly, along with bone loss on the cheek side of the tooth. To join, patients should not have serious general health problems that would make surgery risky, and their tooth should have already had a root canal treatment that didn’t fully fix the problem. The study does not include those with fractured roots, widespread gum disease, or conditions like uncontrolled diabetes or pregnancy that could affect healing. If accepted, participants will undergo a surgical procedure where the researchers will use these materials to try to promote better healing, and they will be monitored to see how well the treatment works.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with no general medical contraindications for oral surgical procedures (ASA-I and ASA-II according to the classification of the American Society of Anesthesiologist's).
• • 2. Patients aged 18 years and above, presenting with chronic suppurative apical periodontitis in at least one tooth,
• • 3. Radiographic evidence of apical radiolucency with periodontal pocket depth exceeding 6 mm confined to buccal aspect of the root.
• • 4. Repeated abscess discharge despite satisfactory root canal treatment. 5.Patients with apicomarginal defects showing a denuded buccal bone plate
• • 6.Failed primary root canal treatment 7.Adequate final restoration with no clinical evidence of coronal leakage.
• Exclusion Criteria:
• • 1. Clinical or radiographic evidence of root fracture.
• • 2. Resorptive processes involving more than apical third of the root.
• • 3. Chronic generalized periodontitis.
• • 4. Failed previous endodontic surgery or failed root canal re-treatment.
• • 5. Any systemic disease contraindicating oral surgery including uncontrolled diabetes and pregnancy, any condition effecting rate of healing like smoking.