ICOPE INTENSE-K Pilot Study

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Jun 24, 2025

Keywords

ClinConnect Summary

This clinical trial, called the ICOPE INTENSE-K Pilot Study, is exploring a new way to help older adults stay healthy as they age. The study focuses on a special care program designed to slow down common problems that come with aging, like weaker immune systems, trouble moving around, and mild memory issues. The goal is to see if this program can help keep people independent and improve their quality of life without using medications.

To take part, participants need to be adults who live on their own but have some difficulty with movement, spend a lot of time sitting or lying down, and show early signs of memory problems based on simple tests. They should also have a body weight that’s at least a little above average. People with serious heart problems, advanced dementia, recent significant weight loss, or those living in nursing homes won’t be able to join. If eligible, participants will take part in the program about three times a week for two months, which includes activities and support aimed at improving their health and mobility. This study is not yet open for enrollment but aims to set a new standard for healthy aging in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Independent-living (ADL ≥5/6)
• • Men and women
• • Mobility impairment (5 Chair-rise test \>12 seconds)
• • Sedentarism (spend six or more hours per day sitting or lying down)
• • Positive screening for cognitive impairment according to the ICOPE screening tool with MMSE \[25-28\]
• • BMI ≥25 kg/m2
• Exclusion Criteria:
• • Unintentional weight loss (≥10%) in past 6 months
• • Dementia
• • Life-threatening illnesses, with a life expectancy (judged by the investigating doctor) of less than 1 year
• • Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina or any other contraindication to physical activity (as determined by a physician) or comorbid disease that would impair ability to participate in the ICOPE intense intervention such as renal failure on hemodialysis, severe psychiatric disorder (depressive participant will not be excluded)
• • Organizational inability (three-time per week during the 60 days)
• • Living in a Nursing-Home
• • Under legal protection measure (guardianship, curatorship, safeguard of justice